Synthesis of a series of novel chiral Lewis base catalysts and their application in promoting asymmetric hydrosilylation of β-enamino esters.
نویسندگان
چکیده
A series of novel chiral Lewis base catalysts were synthesized from L-serine and applied in the hydrosilylation of β-enamino esters, in which the optimal one promoted the reactions to afford a wide variety of β-amino esters in good yields with good enantioselectivities. It is noteworthy that several cyclic substrates were hydrosilylated under the optimal conditions to give the cyclic β-amino esters with high yields, good diastereoselectivities as well as good ee values.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 11 19 شماره
صفحات -
تاریخ انتشار 2013